Friday, June 6, 2008

Humans Started Wearing Shoes as Early as 40,000 Years Ago

shoesShoes do a lot more than simply protect our feet, but most of the time we don't realize the physical changes they inflict. For example, wearing shoes can change the way a human walks and how the weight of the body is being distributed on the feet. In modern humans, who basically can't live without shoes, the physical changes can go as far as to affect the bones and the ligaments. Anthropologists are now using the effects wearing shoes has on the human body to understand when they first became popular on the large scale.

There are several differences, noted by Susan Cachel from the Rutgers University, between the feet of people constantly wearing shoes as compared to those who don't. One of these differences is the fact that wearing shoes can lead to bunions, protuberances of the bone and tissue in the big toe. Additionally, people who don't wear shoes tend to have wider feed, and bigger distances between fingers, while women wearing heals suffer a decrease in the mass of the calf muscles.

Erik Trinkaus from the Washington University says that ever since people started wearing shoes their toe bones began to shrink. The oldest pair of shoes ever discovered is dated 10,000 years ago, although the investigations carried out by Trinkaus revealed nearly three years ago that people were wearing shoes as early as 30,000 years ago. A new study now proves that people may have been wearing shoes 10,000 years earlier.

"Bone, at least to a certain extent, responds during a person's lifetime to the mechanical stresses placed on it. If you work out at the gym, not only will your muscles get bigger, your bones will become thicker.", said Tim Weaver, a anthropologist at University of California.

This is especially visible in humans preceding the appearance of shoes who had thicker toe bones and bigger feet since they were doing most of the walking barefoot. Both Neanderthals and the first modern humans also had bigger bones. However, Trinkaus showed that this began to change some 40,000 years ago, when humans started experiencing changes in the toes.

"They had wimpy toes. I tried to figure out what would take away stresses on the toes, but not the legs, and the answer was shoes", said Trinkaus. Cachel on the other hand believes that Trinkaus' theory is incorrect, because it wasn’t only the toes that started shrinking but fingers as well, probably due to the fact that they stopped being so active.

"If the foot bones are smaller, this probably reflects less walking and physical activity, rather than the invention of supportive footwear", Cachel said.

Alternatively, the changes in the size of the toes could be caused by a diversity boom of the human culture, as the labor divisions started to appear and the time allocated for decorative clothing increased. "The archaeological record shows many changes, including the types of tools people were making and the first definite artwork, and the oldest needles for making clothing appear shortly afterward", Weaver said.

Source @ Softpedia

Cancer vaccine target pinpointed

Cancer vaccineScientists may be one step closer to producing a specific targeted vaccine for killing cancer cells.

UK researchers have pinpointed a protein on immune cells which they hope will help them harness the body's defences to attack a tumour.

A vaccine designed to "home in" on the protein would deliver a message to the immune system to attack the invading cancer, they said.

The research is published in the Journal of Clinical Investigation.

The protein is unique to a type of immune cell called a dendritic cell, which is responsible for triggering the body's defence system.

Its job is to present pathogens or foreign molecules to other cells of the immune system, which in turn eliminate them.

The team at Cancer Research UK's London Research Institute said scientists have been searching for proteins or "tags" on dendritic cells for over 30 years.

In theory a vaccine carrying a foreign molecule from a cancer cell could be targeted to the dendritic cells, which would then prompt the immune system to attack the "invading" cancer. The same approach could be used for treating HIV or malaria, the researchers said.

T cell army

Study leader Dr Caetano Reis e Sousa said the team had found a unique protein called DNGR-1, which could be used to deliver such a vaccine to the door of the dendritic cell.

"Vaccines work by triggering an army of immune cells, called T cells, to attack potentially dangerous foreign molecules, like those found on pathogens.

"Dendritic cells are the messengers, telling the T cells who to attack.

"Vaccines will carry a sample of the offending molecule and deliver it to DNGR-1 on the dendritic cells, which in turn will present the molecule to the armies of T cells and instruct them to attack."

Cancer Research UK's director of cancer information, Dr Lesley Walker, said: "Developing treatments that accurately target cancer and have few serious side-effects is one of Cancer Research UK's top goals.

"The results of this research are an important step towards understanding how to create targeted cancer vaccines in the future."

Source @ BBC

Neo Sci-Fi Collection from MAC

MAC is the latest cosmetics giant to launch a new summer makeup collection, and let me tell you this – it's not for the fain of heart. Its bold, innovative approach to packaging is as surprising and as refreshing as the frost
and shimmer that's inside the bright orange containers. The MAC team welcomes its fans into a "magnetic field of hot fluorescents, modern buffs, beiges and flesh tones […] destined to test the laws of your style gravity" – in other words, we have yet another successful instance of a cosmetics company who invites us to be natural with a rather more flashy twist – and the twist is called "shimmer and shine".

The catch with this collection is that despite the bold, bright containers, the vast majority of colors are on the neutral side. The limited-edition Neo Sci-Fi lipstick comes in five shades: a burnt red with gold pearl (Sci-Fi-Delity), a creamy peach, a mid-tone brown with red pearl (Astral), bright orange (Electro)and a frosty white gold (Sunsonic). The shades are earth-toned, delicate and they promise to drown your lips in shimmering, creamy color for a lasting finish. The tinted lipglasses are back in four shades of creamy plum with just a few flecks of gold (Soft&Slow), bronzed brown with white pearl (Supreme), creamy mid-tone nude peach (Naked Space) and orange with gold pearl (Pink).

The collection also includes a limited-edition shade of Eye Shadow packaged in the shiny neon orange and hi-shine black compact of the Neo Sci-Fi collection, with five very natural nuances of peach, pink and gold, with one darker shade of black brown with silver pearl. There's also a volumizing, lengthening and curling mascara with a creamy black finish and a new patented wand with a v-shaped groove for a more flattering curling effect, two new shimmery shades of Sheertone Shimmer Blush (in peach and mauve), tree natural shades of eyeliner and four nuances of a high gloss formula nail polish in copper, red, yellow and plasma blue.




Source @ Softpedia.com

Penge Online – How to make money online

Penge online or in English make money online, this site offers you easy way to make money or in Danish tjene penge. Tjen penge (make money) as offered by this site, and according to this site can be so easy, within minutes you can make money from $/€200 to $/€500 within one day, care to prove it and try their new methods? Just visit making-money.dk to find out more!


Thursday, June 5, 2008

Explore France

Explore France and find the most romantic places here, you and your love one, you and the whole family, trips with friends, there are lots of interesting attraction, from fashion to great meals, night life to great traditions, France offers you unique and unforgettable experience. You can visit why travel to France to get more information, from accommodation, attractions, meal, must visit places and lots more. Hotel Paris is identical to serial sex & the city, find out more on this site too, you never knows, you may end up to stay here with your love one! Explore France, get more information here at why travel to France!